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Tools for protein design developed and maintained by DeGrado group members are linked to the right.

Tools

E(Z) Depth Potential Position Finder
Calculate the energy minimum of a sequence in standard alpha-helix conformation.

DrawCoil 1.0
Creates helical wheel diagrams for coiled coils of any oligomerization state and orientation.

EZSeq
Calculate the suitability of a sequence for a membrane environment in a standard alpha-helix conformation using the Ez potential.

β-Peptide Rotamer Libaries
Supplementary materials for our paper discussing rotamer libraries for beta-peptide helices. We have calculated libraries for the C3 and C2 positions for both D/L chiralities for 314, 312, 3.0 β-helices. In addition, we present a comparison of libraries computed for different secondary structure environments.

OSTRICh
Use low resolution experimental data to predict the structure of homo-oligomeric transmembrane helical bundles.

The DeGrado Laboratory | Department of Pharmaceutical Chemistry | University of California, San Francisco | San Francisco, CA 94158